Genetic variants IL18 -105G>A and -137G>C associated with susceptibility to migraine

IntroductionFew studies have been conducted into neurogenic inflammation and neuroinflammation in respect of migraine. However, evidence suggests that the immune system may exert an influence over trigeminal activation cortical spreading depression individuals suffering from The interleukin (IL)-18 is a pro-inflammatory cytokine increased plasma levels confirmed with as yet, genetic variants IL-18 not investigated context ObjectiveTo investigate association between IL18 -105G>A (rs360717) -137G>C (rs187238) susceptibility to migraine its clinical characteristics. Subjects MethodsCase control study comprising 307 participants, whom 152 had diagnosis 155 were healthy controls, paired by sex, age, ethnicity BMI. demographic data evaluated. patients interviewed using structured form containing information about type (with or without aura, episodic chronic), age at onset disease, frequency attacks, accompanying symptoms triggered headaches. also answered validated questionnaires evaluate incapacity (Migraine Disability Assessment - MIDAS) impact (Headache Impact Test HIT-6) for migraine, presence allodynia (ASC-12), well anxiety (State Anxiety Inventory STAI 1 2), (Beck Depression Inventory) hyperacusis scale.The identified polymerase chain reaction (PCR) fluorescence PCR products evaluated Step One thermocycler (Applied Biosystems). analyses dominant, codominant, recessive overdominant models. (To see complete abstract, please, check out PDF).